Octapeptide analogs of somatostatin having threonine at the...

Details Octapeptide analogs of somatostatin having threonine at the... Octapeptide analogs of somatostatin having threonine at the...

C - Chemistry, Metallurgy

07

K

C07K 14/655 (2006.01) A61K 38/31 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2046594

2046594 9109056 PCTABS00005 A compound of formula (I), wherein each A1 and A2, independently, is H C1-12 alkyl, C7-10 phenylalkyl, R1CO (where R1 is C1-20 alkyl, C3-20 alkenyl, C3-20 alkenyl, phenyl, naphthyl, or C7-10 phenylalkyl), or R2OCO (where R is C1-10 alkyl or C7-10 phenylalkyl), provided that when one of A1 or A2 is R1CO or R2OCO, the other must be H; each X1 and X2, indepently, is H, F, Cl, Br, OH, CH3, or CF3, provided that at least one of X1 and X2 must be H; A3 is Phe or Tyr; and A4 is OH, NH2, or NH-R3 (wherein R3 is a saturated aliphatic C1-8 alkyl): or a pharmaceutically acceptable salt thereof; a therapeutic composition comprising such compound; and a method of using such compound.

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