Ocular delivery of polymeric delivery formulations

Details Ocular delivery of polymeric delivery formulations Ocular delivery of polymeric delivery formulations

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61F 9/00 (2006.01) A61K 47/34 (2006.01) A61L 31/06 (2006.01) A61L 31/14 (2006.01) A61M 35/00 (2006.01)

Patent

CA 2582374

The present invention provides a flowable composition suitable for use as a controlled release implant. The flowable composition can be administered into the ocular region of a mammal. The composition includes: (a) a biodegradable, biocompatible thermoplastic polymer that is at least substantially insoluble in aqueous medium, water or body fluid; (b) a biological agent, a metabolite thereof, a biological agently acceptable salt thereof, or a prodrug thereof; and (c) a biocompatible organic liquid, at standard temperature and pressure, in which the thermoplastic polymer is soluble. The present invention also provides methods of medical treatment that include administering the flowable composition into the ocular region of a mammal.

La présente invention concerne composition fluide qui convient pour une utilisation sous forme d'implant à libération commandée. Cette composition fluide peut être administrée dans la région oculaire d'un patient. Cette composition contient (a) un polymère biocompatible thermoplastique biodégradable qui est au moins sensiblement insoluble dans un milieu aqueux, dans de l'eau ou dans un liquide organique, (b) un agent biologique, un métabolite de celui-ci , un sel de celui-ci répondant aux normes biologique des agents et un promédicament de celui-ci et, (c) un liquide organique biocompatible à une température et à une pression normalisée , dans lequel ce polymère organique est soluble. C'est invention concerne aussi une technique de traitement médical qui consiste administrer cette composition fluide dans la région oculaire d'un mammifère. ..

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