Ocular diagnosis of alzheimer's disease

Details Ocular diagnosis of alzheimer's disease Ocular diagnosis of alzheimer's disease

A - Human Necessities

61

K

A61K 49/00 (2006.01) C09B 23/14 (2006.01) C09K 11/06 (2006.01)

Patent

CA 2458961

The invention features a method of diagnosing or providing a prognosis regarding the state of Alzheimer's Disease in a mammal by contacting an ocular tissue with a detectably-labeled compound, which binds to an amyloid protein. An increase in binding of the compound to the ocular tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease.

Cette invention concerne une méthode de diagnostic permettant d'établir un pronostic quant à l'état de la maladie d'Alzheimer chez un mammifère. Cette méthode consiste à mettre le tissu oculaire en contact avec un composé à marquage détectable qui se lie à une protéine amyloïde. Toute augmentation de la liaison du composé avec le tissu oculaire par rapport à un niveau témoin normal de liaison est signe que le mammifère est atteint ou risque d'être atteint de la maladie d'Alzheimer.

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