Ocular implants and methods for their manufacture

Details Ocular implants and methods for their manufacture Ocular implants and methods for their manufacture

B - Operations, Transporting

05

D

B05D 3/06 (2006.01) A61F 2/16 (2006.01) A61L 27/00 (2006.01) A61L 27/16 (2006.01) A61L 27/34 (2006.01) B05D 7/02 (2006.01) G02B 1/04 (2006.01) A61F 2/00 (2006.01)

Patent

CA 2052836

A method for modifying an ocular implant polymer surface by the gamma-irradiation or electron beam irradiation induced polymerization thereon of liquid N-vinylpyrrolidone, 2-hydroxyethylmethacrylate or a mixture thereof while maintaining the following conditions. (a) monomer concentration in the range of from about 0.1% to about 50%, by weight; (b) total gamma dose in the range of from about 0.001 to less than about 0.50 Mrad: and (c) gamma dose rate in the range of from about 10 to about 2500 rads/minute or electron beam irradiation dose rate in the range of from about 10 to about 10 8 rads/minute.

Une méthode pour modifier la surface d'un implant oculaire polymérique par polymérisation, induite par irradiation gamma ou par irradiation par faisceau électronique, sur cette surface de N-vinylpyrrolidone, de 2-hydroxyéthyl-méthacrylate ou d'un mélange de ces derniers tout en respectant les conditions suivantes : (a) concentration de monomère dans une étendue variant d'environ 0,1 % à environ 50 %, en poids; (b) dose gamma totale dans une étendue variant d'environ 0,001 à moins d'environ 0,50 Mrad et (c) débit de dose pour l'irradiation gamma dans une étendue variant d'environ 10 à environ 2 500 rads/minute ou débit de dose pour l'irradiation par faisceau électronique dans une étendue variant d'environ 10 à environ 10 8 rads/minute.

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