Ocular therapy in keratoconjuctivitis sicca using topically...

A - Human Necessities – 61 – K

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A61K 31/56 (2006.01) A61K 31/565 (2006.01) A61K 31/568 (2006.01) A61P 27/02 (2006.01) C07J 73/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2367643

The topical application, at a dose rate less than or equal to 0.1 mg day, to the ocular surface or adjacent regions of the eye of a preparation containing a therapeutically effective amount of an androgen or androgen analogue or a therapeutically effective amount of TGF-.beta. is disclosed as a method of relieving the chronic and acute manifestation of dry eye signs and symptoms in keratoconjunctivitis sicca (KCS), for example in Sjögren's syndrome.

L'invention concerne une méthode qui consiste à appliquer localement, sur la surface oculaire ou sur des zones adjacentes de l'oeil, à un débit de dose inférieur ou égal à 0,1 mg/jour, une préparation renfermant une dose thérapeutiquement efficace d'androgènes ou d'analogues d'androgènes ou une dose thérapeutiquement efficace du facteur de croissance transformant bêta (TGF-.beta.), de manière à soulager les manifestations chronique et aiguë des signes et symptômes d'oeil sec dans la kératoconjonctivite sèche, notamment dans le cas du syndrome de Sjögren.

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