Oil-in-water cream containing hydrocortisone butyrate...

A - Human Necessities – 61 – K

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167/196

A61K 31/57 (2006.01) A61K 9/06 (2006.01) A61K 9/10 (2006.01) A61K 47/00 (2006.01)

Patent

CA 1207668

Abstract of the Disclosure An oil-in-water type cream comprising (a) 0.01 to 0.53 by weight of hydrocortisone butyrate propionate, (b) 5 to 50% by weight of a higher paraffinic hydrocarbon, (c) 3 to 15% by weight of a surface-active agent, (d) 30 to 65% by weight of purified water, (e) not more than 20% by weight of a monohydric higher alcohol, (f) not more than 20% by weight of a dihydric or trihydric alcohol, and (g) a pharmaceutically acceptable acid in an amount required to adjust the pH of the cream to a value in the range of 3.5 to 6.5 when it is diluted with water to 20 times its volume.

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