A - Human Necessities – 23 – L
Patent
A - Human Necessities
23
L
A23L 1/30 (2006.01) A23D 9/013 (2006.01) A61K 31/20 (2006.01) A61K 31/23 (2006.01) A61K 31/56 (2006.01) A61K 31/575 (2006.01) A61K 45/06 (2006.01) A61P 9/00 (2006.01)
Patent
CA 2515290
The present invention relates to the use of a composition comprising a combination of diacylglycerol(s) (DAG), mainly 1,3-diacylglycerol(s), and phytosterol and/or phytostanol ester(s) (PSE) dissolved or dispersed in edible oil and/or edible fat, particularly olive, canola and fish oil, in the manufacture of nutritional supplements and orally administrable pharmaceutical preparations which are capable of reducing blood levels of both cholesterol and triglycerides and/or for lowering serum, serum LDL and macrophage oxidation levels, inhibiting the formation of foam cells and/or preventing the deleterious effects generated by lipid-induced oxidative stress. In addition, the composition of the invention, as well as the pharmaceutical preparations thereof, is suitable for the treatment and prevention of conditions related to atherosclerosis, such as cardiovascular disease (CVD), coronary heart disease (CHD) and diabetes mellitus.
La présente invention concerne l'utilisation d'une composition contenant un mélange de diacylglycérole(s) (DAG), essentiellement 1,3-diacylglycérole(s), et d'ester(s) de phytostérol et/ou de phytostanol (PSE) dissous ou dispersés dans une huile comestible et/ou une graisse comestible, notamment, l'huile d'olive, de canola et de poisson, lors de la fabrication d'additifs nutritionnels et de préparations administrables oralement qui permettent de diminuer les concentrations sanguines de cholestérol et de triglycérides et/ou les concentrations d'oxydation de sérum, de LDL de sérum, et de macrophages, d'inhiber la formation de cellules mousseuses et/ou de prévenir les effets délétères engendrés par le stress oxydatif induit par les lipides. Par ailleurs, la composition de cette invention ainsi que les préparations pharmaceutiques correspondantes peuvent être appropriées au traitement et à la prévention de troubles liés à l'athérosclérose, tels qu'une maladie cardiovasculaire, une coronaropathie et le diabète sucré.
Pelled Dori
Platt Dorit
Shulman Avidor
Enzymotec Ltd.
Oyen Wiggs Green & Mutala Llp
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