Oily compositions containing highly fat-soluble drugs

Details Oily compositions containing highly fat-soluble drugs Oily compositions containing highly fat-soluble drugs

A - Human Necessities

61

K

A61K 9/08 (2006.01) A61K 9/48 (2006.01) A61K 31/136 (2006.01) A61K 31/44 (2006.01) A61K 31/4418 (2006.01) A61K 47/14 (2006.01)

Patent

CA 2404381

Oily compositions which contain as the principal agent highly fat-soluble drugs including compounds of the general formula (I), pharmaceutically acceptable salts thereof, and solvates of both, and each further contain (i) a triester of glycerol with a medium-chain fatty acid and/or an ester of propylene glycol with a medium-chain fatty acid, (ii) a triester of glycerol with a long-chain fatty acid, and (iii) a surfactant wherein the rings A, B and C are each an optionally substituted, aromatic carbo- or hetero-cycle or the like, with the proviso that when one or more of the rings A, B and C are each a 5-membered heterocycle, the corresponding W1, W2 and/or W3 are each a bond; X is a single bond, -O-, -CH2-, -NH-, or the like; and Y is lower alkyl, lower alkenyl, or the like.

L'invention concerne des compositions huileuses contenant des médicaments hautement solubles dans la graisse comme agent principal, qui comprennent des composés représentés par la formule (I), des sels pharmaceutiquement acceptables de ceux-ci, et des solvants des deux, chacun d'eux contenant (i) un triester de glycérol avec un acide gras à chaîne moyenne, (ii) un triester de glycérol avec un acide gras à chaîne longue, et (iii) un tensioactif. Dans la formule (I), les cycles A, B, et C représentent chacun un cycle carboné ou hétéro ou analogue aromatique éventuellement substitué à condition que au moins l'un des cycles A, B, et C soit un hétérocycle à 5 chaînons; les W1, W2, et/ou W3 correspondant représentent chacun une liaison simple, -O-, -CH2-, -NH-, ou analogue; et Y représente alkyle inférieur, alcényle inférieur, ou analogue.

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