Olfactory ensheathing cells isolated from the lamina propria

Details Olfactory ensheathing cells isolated from the lamina propria Olfactory ensheathing cells isolated from the lamina propria

C - Chemistry, Metallurgy

12

N

C12N 5/08 (2006.01) A61K 41/00 (2006.01) C12N 5/06 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2389121

A method is described for isolating ensheathing cells, in particular those from olfactory lamina propria and use of the isolated ensheathing cells and lamina propria respectively in transplantation. Isolated lamina propria and ensheathing cells from the olfactory mucosa are well suited for autologous transplantation, where the donor and recipient are the same, as surgical biopsy of the olfactory mucosa is less damaging than isolating tissue from other location of a person's body, for example the olfactory bulb. Transplantation is particularly directed to neural regions (for example the brain, spinal cord and/or peripheral nerves) of a human to assist recovery of acute and chronic nerve damage following surgery or trauma.

L'invention concerne une méthode d'isolement de cellules d'engainement, en particulier de cellules de la lamina propria olfactive, ainsi que l'utilisation des cellules d'engainement isolées et de la lamina propria respectivement en transplantation. Les cellules isolées de lamina propria et d'engainement prélevées sur la muqueuse olfactive sont bien adaptées à une greffe autologue, dans laquelle le donneur et le receveur sont identiques, étant donné que la biopsie chirurgicale de la muqueuse olfactive engendre une détérioration moindre par rapport à l'isolement de tissu prélevé en d'autres endroits du corps d'une personne, par exemple le bulbe olfactif. La greffe est dirigée en particulier vers les régions neurales (par exemple le cerveau, la moelle épinière et/ou les nerfs périphériques) d'un patient humain afin de contribuer à récupérer d'une détérioration nerveuse aiguë et chronique après une chirurgie ou un trauma.

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