Olfactory neuron cultures and method of making and using the...

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G01N 33/53 (2006.01) A61K 49/00 (2006.01) A61P 25/28 (2006.01) C12Q 1/26 (2006.01) G01N 33/18 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2415084

Olfactory neuron cultures and methods of making and using the same are disclosed. The olfactory neuron cultures may be used to study oxidative stress- related disorders and diseases such as Alzheimer's disease. The olfactory neuron cultures may be used to screen candidate compounds for those which reduce, inhibit or prevent oxidative stress or damage. The compounds which reduce, inhibit or prevent oxidative stress or damage may be used to treat Alzheimer's disease and other oxidative stress-related disorders and diseases.

L'invention concerne des cultures de neurones olfactifs et des procédés relatifs à leur élaboration et à leur utilisation. On peut utiliser ces cultures pour étudier les troubles et les maladies liés à l'agression oxydative (par exemple, maladie d'Alzheimer). On peut aussi utiliser lesdites cultures pour cribler des composés candidats à la réduction, l'inhibition ou la prévention de l'agression ou bien des dégâts de type oxydatif. Enfin, il est possible d'utiliser les composés qui produisent ces effets pour traiter la maladie d'Alzheimer ou d'autres troubles et maladies liés à l'agression oxydative.

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