Olgiopeptide derivatives of phosphonic acid

Details Olgiopeptide derivatives of phosphonic acid Olgiopeptide derivatives of phosphonic acid

C - Chemistry, Metallurgy

07

F

530/5.04, 530/7.

C07F 9/38 (2006.01) C07K 5/06 (2006.01) C07K 5/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1108125

ABSTRACT OF THE DISCLOSURE A process for the manufacture of compounds which are peptide derivatives of formula I Image (I) wherein R1 is H, CH3, CH2OH or mono-, di- or trihalomethyl R2 is the characterising group of an .alpha.-amino acid normally found in proteins or lower alkyl or hydroxy-(lower alkyl) other than such characterising group; R3 is lower alkyl, lower cycloalkyl, lower alkenyl, aryl or aryl-(lower alkyl); R4 is H or lower alkyl; n = 1, 2 or 3; configuration at C-atom (a) is (R) when Rl is other than H; configuration at C-atom (b) is (L) when R2 is other than H; and salts thereof. The process comprises cleaving off by methods known per se the protecting group(s) in a compound of formula Ia Image (Ia) wherein (a), (b), n, R3 and R4 are as above; R5 and R6 are H or lower alkyl protecting groups; R7 is protecting group; R10 is R1 plus protected hydroxymethyl; R20 is R2 (except that functional group(s) present in R2 are protected). These peptide derivatives possess an antibacterial activity against a wide range of gram-positive and gram-negative bacteria, particularly against Streptococcus faecalis and Haemophilus influenzae.

317617

Affiliated with

Also associated with

Rating

Olgiopeptide derivatives of phosphonic acid does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Olgiopeptide derivatives of phosphonic acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Olgiopeptide derivatives of phosphonic acid will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-353976