C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) A61K 31/70 (2006.01) C07H 19/10 (2006.01) C07H 19/20 (2006.01) C07H 23/00 (2006.01)
Patent
CA 2103062
Oligodeoxyribonucleotides in which at least two 2'- deoxy-B-D-erythro-pentofuranosoyl groups are replaced by 2'-deoxy-B-D-threo-pentofuranosyl groups at both the 5' end and 3' end, and oligodeoxyribonucleotides in which at least 20 % of the 2'-deoxy-B-D-erythro-pentofuranosyl groups in consecutive nucleotide building blocks are replaced by 2'-deoxy-B-D-threo-pentofuranosyl groups and which are composed of 6 to 100 nucleotide building blocks, are suitable for the inhibition of the expression of viral genes and oncogenes by the antisense principle and can be used for the production of pharmaceutical agents with antiviral activity.
Muhlegger Klaus
Rosemeyer Helmut
Seela Frank
von Der Eltz Herbert
Boehringer Mannheim Gmbh
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Roche Diagnostics Gmbh
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