Oligo-amine/oligo-carboxy sulfonamides

Details Oligo-amine/oligo-carboxy sulfonamides Oligo-amine/oligo-carboxy sulfonamides

C - Chemistry, Metallurgy

07

C

C07C 311/16 (2006.01) A61P 9/12 (2006.01) C07C 311/14 (2006.01) C07C 311/46 (2006.01) C07D 277/16 (2006.01) C07D 277/80 (2006.01) C07D 285/125 (2006.01)

Patent

CA 2372731

The invention relates to new sulfonamide derivatives of aryl or heterocyclic compounds and to their pharmaceutically acceptable salts. The new derivatives of the invention can be obtained with chemical synthetic processes known in the art. For example, they can be prepared by mono- or poly-condensation of a suitably substituted sulfonamide compound. The sulfonamide compounds of the invention are active, in particular, as inhibitors of carbonic anhydrase isoenzymes and therefore they can be useful in therapy, in particular in the ophthalmic field. In fact these compounds are able to decrease the intraocular pressure in glaucoma and to improve the protection of the retina. The new sulfonamide derivatives can be administered to humans in the form of different pharmaceutical preparations, in particular eye drops. -195-

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