Oligo or polyalkylene glycol-coupled thrombin inhibitors

Details Oligo or polyalkylene glycol-coupled thrombin inhibitors Oligo or polyalkylene glycol-coupled thrombin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 207/08 (2006.01) A61K 47/48 (2006.01) C07D 401/06 (2006.01) C07D 405/12 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01) C07K 5/068 (2006.01) C08G 65/333 (2006.01) C12N 9/50 (2006.01)

Patent

CA 2431487

The invention relates to novel, covalent oligo and polyalkylene glycol conjugates containing synthetic inhibitors of trypsin-type serine protease, in particular inhibitors of the haemocoagulation protease thrombin. The invention also relates to synthetic intermediate stages required in the production of said conjugates and to the use of the latter for producing active agents for the treatment or prophylaxis of thrombotic complications.

L'invention concerne de nouveaux conjugués oligo-glycol et polyalkylène-glycol covalents comportant des inhibiteurs synthétiques de sérine-protéases de type trypsine, en particulier des inhibiteurs de la protéase de coagulation sanguine thrombine. L'invention concerne également des étapes intermédiaires synthétiques destinées à la fabrication des conjugués selon l'invention, ainsi que leur utilisation dans la fabrication d'agents actifs pour la thérapie ou la prophylaxie de complications thrombotiques.

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