C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 211/14 (2006.01) A61K 31/132 (2006.01) A61K 31/133 (2006.01) A61P 35/00 (2006.01) C07C 215/18 (2006.01)
Patent
CA 2463771
Oligoamine compounds with anti-cancer and anti-proliferative activity are provided, as well as methods for making and using the compounds. The compounds are shown to be active against prostate cancer cell lines and against prostate cancer tumors in mice. The compounds are also useful in treatment of breast cancer and other cancers.
L'invention concerne des composés oligoamine ayant une activité anticancéreuse et anti-proliférative, ainsi que des procédés pour la fabrication et l'utilisation de ces composés. On a montré que les composés selon l'invention sont actifs contre des lignées cellulaires du cancer de la prostate et contre des tumeurs du cancer de la prostate chez la souris. Les composés selon l'invention sont également utiles dans le traitement du cancer du sein et d'autres cancers.
Basu Hirak S.
Blokhin Andrei V.
Frydman Benjamin
Marton Laurence J.
Reddy Venodhar K.
Borden Ladner Gervais Llp
Progen Pharmaceuticals Inc.
Slil Biomedical Corporation
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