C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 235/18 (2006.01) A61K 31/4184 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) C07D 235/20 (2006.01) C12N 15/87 (2006.01) G01N 33/52 (2006.01)
Patent
CA 2389778
The invention concerns oligobenzimidazole derivatives capable of combining with nucleic acids of general formula (I) wherein: R represents a hydrogen atom or certain substituents; n is an integer equal to 2, 3, 4 or 5; and R' represents a -O-R¿3?, -S-R¿3?, NHR¿3? group or -O-CO-NH-R¿3? and R¿3? represents an alkyl group; or R' represents a -NR¿4?R¿5? group or -O-CO-NR¿4?R¿5? and R¿4? and R¿5? represent each an alkyl group, the alkyl radicals containing 12 to 22 carbon atoms; their salts, compositions containing them and their uses, for example for transferring in vitro, in vivo or ex vivo nucleic acids into cells or for visual display of nucleic acids administered by fluorescence.
L'invention se rapporte à des dérivés d'oligobenzimidazoles capables de s'associer avec les acides nucléiques de formule générale (I) dans laquelle R représente un atome d'hydrogène ou certains substituents, n est un entier égal à 2, 3, 4 ou 5 et R' représente un groupe -O-R3, -S-R3, NHR3, ou bien -O-CO-NH- R3 et R3 représente un groupe alkyle, ou bien R' représente un groupe -NR4R5 ou bien -O-CO-NR4R5 et R4 et R5 représentent chacun un groupe alkyle, les radicaux alkyles contenant 12 à 22 atomes de carbone, leurs sels, les compositions qui les contiennent et leurs utilisations, par exemple pour le transfert in vitro, in vivo ou ex vivo d'acides nucléiques dans les cellules ou la visualisation des acides nucléiques administrés par fluorescence.
Bessodes Michel
Byk Gerardo
Pitard Bruno
Scherman Daniel
Soto Javier
Aventis Pharma S.a.
Robic
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