Oligodendrocyte precursor cell proliferation regulated by...

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/22 (2006.01) A61K 35/30 (2006.01) A61K 38/18 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2664629

A method as disclosed, which in one embodiment is for treating a disease associated with demyelination by increasing oligodendrocytes and oligodendrocyte precursor cells in a mammal through administration of prolactin. Prolactin can be used alone, or in conjunction with administration of neural stem cells or oligodendrocyte precursor cells. Optionally, additional compounds that improve oligodendrocyte proliferation, differentiation or survival are administered concurrently with prolactin.

La présente invention concerne un procédé qui permet de traiter une maladie associée à une démyélination en augmentant les oligodendrocytes et les cellules précurseurs d'oligodendrocytes chez un mammifère par l'administration de prolactine. La prolactine peut être utilisée seule ou combinée à l'administration de cellules souches neurales ou de cellules précurseurs d'oligodendrocytes. Facultativement, des composés supplémentaires qui améliorent la prolifération, la différenciation ou la survie des oligodendrocytes sont administrés en même temps que la prolactine.

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