Oligodeoxynucleotides with 5'-linked chemical groups, method...

Details Oligodeoxynucleotides with 5'-linked chemical groups, method... Oligodeoxynucleotides with 5'-linked chemical groups, method...

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2049361

2049361 9012802 PCTABS00002 Method of synthesis is provided for novel oligodeoxynucleotides 5' linked to covalently attached chemical groups via intermediate linked phosphoramidites. The synthesis of the covalently attached chemical group to a phosphoramidite moiety occurs outside the automatic synthesizer, followed by application of this complex as a terminator of the 5' end of a phosphate-modified oligodeoxynucleotide in the automatic synthesizer. The compounds are used to attenuate or destroy mammalian gene expression or viral activity.

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