Oligomer-protease inhibitor conjugates

Details Oligomer-protease inhibitor conjugates Oligomer-protease inhibitor conjugates

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2679482

The invention provides protease inhibitors that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the protease inhibitors not attached to the water-soluble oligomer.

L'invention concerne des médicaments à petites molécules chimiquement modifiés par une fixation covalente d'un oligomère hydrosoluble. Un conjugué de l'invention, lorsqu'administré par une quelconque d'un certain nombre de voies d'administration, présente des caractéristiques qui sont différentes du médicament à petites molécules non lié à l'oligomère hydrosoluble.

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