Oligomeric compounds and compositions for the use in...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/11 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2640058

Compounds, compositions and methods are provided for modulating the levels expression, processing and function of miRNAs. The compositions comprise oligomeric compounds targeted to small non-coding RNAs and miRNAs. The oligomeric compounds possess potent miRNA inhibitory activity, and further exhibit improved therapuetic index. Further provided are methods for selectively modulating miRNA activity in a cell.

L'invention concerne des composés, compositions et procédés destinés à moduler les niveaux d'expression, le traitement et la fonction de miARN. Les compositions comprennent des composés oligomères destinés à cibler de petits ARN et miARN non codants. Lesdits composés oligomères possèdent une activité puissante d'inhibition des miARN et font également preuve d'un indice thérapeutique amélioré. L'invention concerne également des procédés permettant d'inhiber de façon sélective l'activité des miARN dans une cellule.

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