C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) A61K 48/00 (2006.01) C07H 21/02 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2533701
Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non- coding RNAs are also provided.
La présente invention concerne des composés, des compositions et des procédés permettant de moduler l'expression et la fonction de petits ARN non-codants. Les compositions décrites dans cette invention comprennent des composés oligomères ciblés sur les petits ARN non-codants. L'invention concerne également des procédés d'utilisation de ces composés pour moduler des petits ARN non-codants ainsi que des cibles avals de ces ARN, et pour diagnostiquer et traiter une maladie associée à des petits ARN non-codants.
Baker Brenda F.
Bennett C. Frank
Bhat Balkrishen
Esau Christine
Freier Susan M.
Isis Pharmaceuticals Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Regulus Therapeutics Inc.
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