C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/70 (2006.01) A61K 45/06 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07H 19/02 (2006.01) C07H 21/04 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2480311
Oligonucleotides directed against the hypoxia-inducible factor-l.alpha.. (HIF- 1.alpha.)- gene are provided for modulating the expression of HIF-1.alpha.. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the HIF-1.alpha.. Methods of using these compounds for modulation of HIF-1.alpha.. expression and for the treatment of diseases associated with the hypoxia-inducible factor- 1.alpha. are provided. Examples of diseases are cancer and pre-eclampsia. The oligonucleotides may be composed of deoxyribonucleosides, a nucleic acid analogue, or Locked Nucleic Acid (LNA) or a combination thereof.
L'invention concerne des oligonucléotides dirigés contre le gène du facteur-1.alpha. (HIF-1.alpha.) qui est inductible par hypoxie pour moduler l'expression de ce facteur HIF-1.alpha.. Les compositions selon l'invention comprennent des oligonucléotides, en particulier des oligonucléotides antisens, ayant pour cible des acides nucléiques codant le facteur HIF-1.alpha.. L'invention se rapporte en outre à des procédés d'utilisation de ces composés pour moduler l'expression de HIF-1.alpha. et traiter des maladies associées au facteur-1.alpha., telles que le cancer et la prééclampsie. Lesdits oligonucléotides peuvent être composés de déoxyribonucléosides, d'un analogue d'acide nucléique ou d'un LNA (acide nucléique bloqué) ou d'une combinaison de ceux-ci.
Hog Anja Molhart
Kristjansen Paul E. G.
Thrue Charlotte Albaek
Enzon Pharmaceuticals Inc.
Santaris Pharma A/s
Smart & Biggar
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