Oligomeric compounds for the modulation of ras expression

Details Oligomeric compounds for the modulation of ras expression Oligomeric compounds for the modulation of ras expression

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2515644

Oligonucleotides directed against the Ha-ras gene are provided for modulating the expression of Ha-ras. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the Ha-ras. Methods of using these compounds for modulation of Ha-ras expression and for the treatment of diseases associated with either overexpression of Ha-ras, expression of mutated Ha-ras or both are provided. Examples of diseases are cancer such as lung, breast, colon, prostate, pancreas, lung, liver, thyroid, kidney, brain, testes, stomach, intestine, bowel, spinal cord, sinuses, bladder, urinary tract or ovaries cancers. The oligonucleotides may be composed of deoxyribonucleosides or a nucleic acid analogue such as for example locked nucleic acid or a combination thereof.

L'invention concerne des oligonucléotides dirigés contre le gène Ha-ras, destinés à la modulation de l'expression de Ha-ras. L'invention concerne également des compositions comprenant des oligonucléotides, en particulier des oligonucléotides antisens, dirigés contre des acides nucléiques codant pour le gène Ha-ras. L'invention concerne également des méthodes d'utilisation de ces composés pour la modulation de l'expression de Ha-ras et le traitement de maladies liées à la surexpression de Ha-ras, à l'expression d'une mutation de Ha-ras ou toutes les deux. Ces maladies comprennent notamment le cancer du poumon, du sein, du côlon, de la prostate, du pancréas, du foie, de la thyroïde, du rein, du cerveau, du testicule, de l'estomac, de l'intestin, de la moelle épinière, des sinus, de la vessie, des voies urinaires ou de l'ovaire. Ces oligonucléotides peuvent être composés de désoxyribonucléosides ou d'un analogue de l'acide nucléique, tel que, par exemple, un acide nucléique verrouillé, ou d'un mélange de ces derniers.

Affiliated with

Also associated with

Rating

Oligomeric compounds for the modulation of ras expression does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Oligomeric compounds for the modulation of ras expression, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oligomeric compounds for the modulation of ras expression will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1702712