C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2515623
Oligonucleotides directed against the survivin gene are provided for modulating the expression of survivin. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the survivin. Methods of using these compounds for modulation of survivin expression and for the treatment of diseases associated with either overexpression of survivin, expression of mutated survivin or both are provided. Examples of diseases are cancer such as lung, breast, colon, prostate, pancreas, lung, liver, thyroid, kidney, brain, testes, stomach, intestine, bowel, spinal cord, sinuses, bladder, urinary tract or ovaries cancers. The oligonucleotides may be composed of deoxyribonucleosides or a nucleic acid analogue such as for example locked nucleic acid or a combination thereof.
L'invention concerne des oligonucléotides dirigés contre le gène de la survivine, qui permettent de moduler l'expression de la survivine. Ces compositions comprennent des oligonucléotides, notamment des oligonucléotides antisens, ciblés sur des acides nucléiques qui codent pour la survivine. L'invention concerne aussi des procédés d'utilisation de ces composés pour moduler l'expression de survivine et traiter des maladies associées à une surexpression de la survivine et/ou à une expression de survivine mutante. Ces maladies comprennent par exemple les cancers du poumon, du sein, du côlon, de la prostate, du pancréas, du foie, de la thyroïde, du rein, du cerveau, des testicules, de l'estomac, de l'intestin, de la moelle épinière, des sinus, de la vessie, des voies urinaires ou de l'ovaire. Les oligonucléotides peuvent être composés de désoxyribonucléosides ou d'un analogue d'acide nucléique tel qu'un acide nucléique verrouillé, ou d'une combinaison de ceux-ci.
Hansen Bo
Petersen Kamille Dumong
Thrue Charlotte Albaek
Westergaard Majken
Wissenbach Margit
Enzon Pharmaceuticals Inc.
Santaris Pharma A/s
Smart & Biggar
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