C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01)
Patent
CA 2515554
Oligonucleotides directed against the TRX gene are provided for modulating the expression of TRX. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the TRX. Methods of using these compounds for modulation of TRX expression and for the treatment of diseases associated with either overexpression of TRX, expression of mutated TRX or both are provided. Examples of diseases are cancer such as lung, colon, prostate, pancreas, lung, liver, thyroid, kidney, brain, testes, stomach, intestine, bowel, spinal cord, sinuses, bladder, urinary tract or ovaries cancers. The oligonucleotides may be composed of deoxyribonucleosides or a nucleic acid analogue such as for example locked nucleic acid or a combination thereof.
L'invention concerne des oligonucléotides dirigés contre le gène TRX afin de moduler l'expression de TRX. Ces compositions contiennent des oligonucléotides ciblés vers des acides nucléiques codant TRX. L'invention porte aussi sur des procédés d'utilisation de ces composés pour la modulation de l'expression de TRX et pour le traitement de maladies associées soit à la surexpression de TRX, soit à l'expression de TRX muté, ou aux deux. Parmi ces maladies figurent le cancer tel le cancer des poumons, du sein, du colon, de la prostate, du pancréas, du foie, de la thyroïde, des reins, du cerveau, des testicules, de l'estomac, de l'intestin, de la moelle épinière, des sinus, de la vessie, du tractus urinaire ou des ovaires. Ces oligonucléotides peuvent être composés deoxyribonucléosides ou d'un acide nucléique analogue tel un acide nucléique verrouillé ou une combinaison des deux.
Hansen Bo
Petersen Kamille Dumong
Thrue Charlotte Albaek
Westergaard Majken
Wissenbach Margit
Gowling Lafleur Henderson Llp
Santaris Pharma A/s
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