Oligomeric compounds having modified phosphate groups

Details Oligomeric compounds having modified phosphate groups Oligomeric compounds having modified phosphate groups

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/7088 (2006.01) A61K 31/7125 (2006.01) A61K 48/00 (2006.01) C08F 130/02 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2482440

Oligomeric compounds having at least one phosphorothioate monoester are provided having increased nuclease resistance and binding affinity to a complementary strand of nucleic acid. Such oligomeric compounds are useful for diagnostics and other research purposes, for modulating the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions responsive to oligonucleotide therapeutics.

L'invention concerne des composés oligomères ayant au moins un monoester phosphorothioate, qui présentent une résistance accrue à la nucléase et une affinité de liaison avec un brin complémentaire d'acide nucléique. Ces composés sont utiles pour les applications de diagnostic et autres applications de recherche, pour la modulation de l'expression d'une protéine dans des organismes, et pour le diagnostic, la détection et le traitement d'autres affections qui réagissent à des moyens thérapeutiques à base d'oligonucléotides.

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