Oligomeric immunoglobulins

Details Oligomeric immunoglobulins Oligomeric immunoglobulins

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/40 (2006.01) C07K 16/00 (2006.01) C07K 16/12 (2006.01) C12N 5/10 (2006.01) C12P 21/08 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2045150

2045150 9106305 PCTABS00005 Novel oligomeric monoclonal antibodies with high avidity for antigen are described. The oligomers, typically of the IgG class, are secreted having two or more immunoglobulin monomers associated together to form tetravalent or hexavalent IgG molecules. The oligomers can be formed by substantially duplicating regions of the light chain, particularly the variable region. Oligomeric antibodies of the IgG isotype cross the placenta and can provide passive immunity to a fetus, which is particularly important for protecting newborns against pathogens such as group B streptococci.

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