Oligomers having improved stability at acid ph

Details Oligomers having improved stability at acid ph Oligomers having improved stability at acid ph

C - Chemistry, Metallurgy

07

H

C07H 21/02 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2152672

Acid resistant oligonucleotides modified by alkylation at the 2'-O-position are suitable for oral administration. Orally acceptable formulations prepared With the disclosed modified oligonucleotides as active ingredients are also provided.

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