C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/02 (2006.01) C07H 21/04 (2006.01) C12N 15/09 (2006.01) C12N 15/85 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) A61P 1/16 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 17/02 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2281086
Oligomers which inhibit expression of a collagen gene are described. It is believed that each oligomer, when introduced into a cell, forms a transcription-inhibiting complex composed of the oligomer and the collagen- gene promoter region. The oligomer, preferably a phosphorothioate deoxyoligonucleotide, preferably binds in the antiparallel orientation to the polypurine strand of a polypurine-polypyrimidine region of the promoter region of a mammalian .alpha.1(I) collagen gene.
L'invention concerne des oligomères inhibant l'expression d'un gène de collagène. On estime que chaque oligomère, une fois introduit dans une cellule, forme un complexe inhibant la transcription, composé de l'oligomère et de la région promotrice du gène de collagène. Cet oligomère, de préférence un désoxyoligonucléotide de phosphorothioate, se lie de préférence selon une orientation antiparallèle au brin de polypurine de la région polypurine-polypyrimidine de la région promotrice d'un gène de collagène .alpha.1(I) de mammifère.
Guntaka Ramareddy V.
Kandala Jagannadhachari
Kovacs Atilla
Weber Karl Theodore
Gowling Lafleur Henderson Llp
Guntaka Ramareddy V.
LandOfFree
Oligomers which inhibit expression of collagen genes does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Oligomers which inhibit expression of collagen genes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oligomers which inhibit expression of collagen genes will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1460568