Oligomers which inhibit expression of collagen genes

Details Oligomers which inhibit expression of collagen genes Oligomers which inhibit expression of collagen genes

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2232089

Oligomers which inhibit expression of a collagen gene are described. It is believed that each oligomer, when introduced into a cell, forms a transcription-inhibiting complex composed of the oligomer and the collagen gene promoter region. The oligomer, preferably a phosphorothioate deoxyoligonucleotide, preferably binds in the antiparallel orientation to the polypurine strand of a polypurine-polypyrimidine region of the promoter region of a mammalian .alpha.1(I) collagen gene.

L'invention se rapporte à des oligomères inhibant l'expression d'un gène du collagène. On pense que chaque oligomère, lorsqu'il est introduit dans une cellule, forme un complexe inhibant la transcription constitué de l'oligomère et de la région promoteur du gène du collagène. L'oligomère, de préférence un phosphorothioate désoxyoligonucléotide, se fixe dans le sens antiparallèle au brin de polypurine d'une région polypurine-polypyrimidine de la région promoteur d'un gène mammalien du collagène .alpha.1(I).

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