Oligomers which inhibit the expression of interleukin genes

Details Oligomers which inhibit the expression of interleukin genes Oligomers which inhibit the expression of interleukin genes

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2269722

Oligomers for inhibiting expression of interleukin genes are described. It is believed that each oligomer, when introduced into a cell, is capable of forming a transcription-inhibiting complex composed of the oligomer and an interleukin gene. The oligomer preferably binds in the antiparallel orientation to the polypurine strand of a polypurine-polypyrimidine region of the interleukin gene.

L'invention concerne des oligomères destinés à inhiber l'expression de gènes de l'interleukine. On pense que chaque oligomère, une fois introduit dans une cellule, peut former un complexe d'inhibition-transcription, composé de l'oligomère et d'un gène de l'interleukine. Cet oligomère se fixe, de préférence, dans un sens antiparallèle à la souche purine d'une région polypurine-polypyrimidine du gène de l'interleukine.

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