Oligonucleotide alkylphosphonates and alkylphosphonothioates

Details Oligonucleotide alkylphosphonates and alkylphosphonothioates Oligonucleotide alkylphosphonates and alkylphosphonothioates

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2154578

Disclosed is an oligonucleotide analog comprising at least one ribonucleotide alkylphosphonate or alkylphosphonotioate. This analog is preferably from 2 to 60 nucleotides in length and has at least one ribonucleotide substituted at the 2' position of its ribose group. Also disclosed are therapeutic formulations comprising this oligonucleotide analog, methods of inhibiting the expression of a gene from a virus, organism, or cell, the expression of which is associated with a disease state, and methods of treating a mammal infected with a virus or pathogenic organism or afflicted with a disorder resulting from the expression of a cellular gene.

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