Oligonucleotide alkylphosphonothioates

Details Oligonucleotide alkylphosphonothioates Oligonucleotide alkylphosphonothioates

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2140542

2140542 9402499 PCTABScor01 The invention provides improved oligonucleotides having greater resistance to nucleolytic degradation by virtue of having alkylphosphonothioate or arylphosphonothioate internucleotide linkages.

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