Oligonucleotide analogs, their preparation and use

Details Oligonucleotide analogs, their preparation and use Oligonucleotide analogs, their preparation and use

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07F 9/24 (2006.01) C07F 9/48 (2006.01) C07F 9/553 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2087818

The invention relates to compounds of the formula I (see formula I) where R1 is H, alkyl, acyl, aryl or a phosphate residue; R2 is H, OH, alkoxy, NH2 or halogen; B is a base customary in nucleotide chemistry; a is O or CH2; n is an integer from 1 to 100; W = O, S or Se; V = O, S or NH; Y = O, S, NH or CH2; Y' = O, S, NH or alkylene; X = OH or SH; U = OH, SH, SeH, alkyl, aryl or amine and Z = OH, SH, SeH, an optionally substituted radical from the group comprising alkyl, aryl, heteroaryl, alkoxy or amino, or a group which favors intracellular uptake or serves as the label of a DNA probe or attacks the target nucleic acid during hybridization, where if Z = OH, SH, CH3 or OC2H5, at least one of the groups X, Y, Y', V or W is not OH or O or R1 is not H; a process for their preparation and their use as inhibitors of gene expression, as probes for detecting nucleic acids and as aids in molecular biology.

Affiliated with

Also associated with

Rating

Oligonucleotide analogs, their preparation and use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Oligonucleotide analogs, their preparation and use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oligonucleotide analogs, their preparation and use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1424632