Oligonucleotide analogs with terminal 3'-3' or 5'-5'...

Details Oligonucleotide analogs with terminal 3'-3' or 5'-5'... Oligonucleotide analogs with terminal 3'-3' or 5'-5'...

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) C07H 19/10 (2006.01) C07H 19/20 (2006.01) G01R 15/18 (2006.01)

Patent

CA 2045891

1 Oligonucleotide analogs with terminal 3'-3' or 5'-5' internucleotide linkages Therapeutically utilizable oligonucleotides of the formulae I and II have been obtained by introduction of terminal 3'-3' and 5'-5' linkages. These compounds are stable to nucleases and suppress the biological function of nucleic acids.

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