C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/00 (2006.01) C07H 21/02 (2006.01) C07K 14/00 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2475373
The present invention relates generally to oligonucleotide analogues that include novel protein nucleic acid molecules (PNAs), particularly monomers, dimers, oligomers thereof and methods of making and using these oligonucleotide analogues. The PNAs of the present invention are characterized as including a variety of classes of molecules, such as, for example, hydroxyproline peptide nucleic acids (HypNA), and serine peptide nucleic acids (SerNA). The present invention also includes the use of oligonucleotides of the present invention in antisense and homologous recombination constructs and methods.
De manière générale, la présente invention a trait à des analogues d'oligonucléotides comportant de nouvelles molécules protéiques d'acide nucléique (protéines PNA), notamment des monomères, des dimères, des oligomères de celles-ci et des procédés permettant la fabrication et l'utilisation desdits analogues d'oligonucléotides. Les protéines PNA de la présente invention sont caractérisées en ce qu'elles comprennent une variété de classes de molécules, telles que, par exemple, des protéines PNA d'hydroxyproline (HypNA) et des protéines PNA de sérine (SerNA). La présente invention a trait également à l'utilisation des oligonucléotides de la présente invention dans des constructions et des procédés de recombinaison antisens et homologue.
Archdeachon John
Archdeacon Dorothy
Choob Mikhail
Efimov Vladimir
Fernandez Joseph
Active Motif
Archdeachon John
Archdeacon Dorothy
Choob Mikhail
Efimov Vladimir
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