Oligonucleotide and use thereof

Details Oligonucleotide and use thereof Oligonucleotide and use thereof

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) A61K 31/711 (2006.01) A61K 31/7125 (2006.01) A61P 37/06 (2006.01) C07K 14/705 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2638176

An oligonucleotide with a nucleotide sequence of 5'-cctcctcctcctcctcctcctcct- 3' inhibits proliferation of human PBMC activated by TLR9 agonist and interferon production from human PBMC induced by TLR9 agonist, HSV-1, flu virus and serum from SLE patients, and rescues the mice from cytokine-mediated lethal shock. This oligonucleotide can be used as a remedy for the treatment of systemic lupus erythematosus (SLE), sepsis, multiple organ dysfunction syndromes and other immune-mediated disorders.

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