Oligonucleotide compositions and their use to induce apoptosis

Details Oligonucleotide compositions and their use to induce apoptosis Oligonucleotide compositions and their use to induce apoptosis

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/7088 (2006.01) A61K 31/7115 (2006.01) A61K 48/00 (2006.01) A61P 9/10 (2006.01) A61P 11/06 (2006.01) A61P 19/02 (2006.01) A61P 35/00 (2006.01) C12N 15/11 (2006.01) G01N 33/48 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2457783

The present invention provides novel synthetic oligonucleotide sequences (hereinafter sequence) of3 to 9 bases in length comprising one or more non-DNA bases wherein the bases are nebularine, hypoxanthine, or uracil, or combinations of nebularine, hypoxanthine and uracil bases. These sequences optionally further comprise one or more guanine bases or one or more thymine bases, or combinations thereof. The present invention also provides for the use of these compositions in the medicaments and methods of using these compositions and medicaments to induce responses in cells, and to treat diseases and conditions characterized by undesired cellular proliferation such as autoimmune disease, lymphoproliferative disease, inflammation or cancer.

L'invention concerne des séquences oligonucléotidiques synthétiques (séquence décrite ci-après) constituées de 3 à 9 bases en longueur. Ces séquences oligonucléotidiques comprennent une ou plusieurs bases non ADN qui sont la nébularine, l'hypoxanthine ou l'uracile ou des combinaisons de bases nébularine, hypoxanthine et uracile. Ces séquences comprennent éventuellement une ou plusieurs bases guanine ou une ou plusieurs bases thymine ou des combinaisons de ces dernières. L'invention concerne également l'utilisation de ces compositions dans des médicaments ainsi que des méthodes d'utilisation de ces compositions et de ces médicaments dans le but d'induire des réponses dans des cellules et de traiter des maladies et des états pathologiques caractérisés par une prolifération cellulaire non souhaitée, notamment des maladies auto-immunes, des maladies lymphoprolifératives, des inflammations ou le cancer.

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