Oligonucleotide compositions with enhanced efficiency

Details Oligonucleotide compositions with enhanced efficiency Oligonucleotide compositions with enhanced efficiency

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01) A61P 1/04 (2006.01) A61P 9/00 (2006.01) A61P 17/06 (2006.01) A61P 27/02 (2006.01) A61P 29/00 (2006.01) A61P 31/12 (2006.01) A61P 31/18 (2006.01) A61P 31/20 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) A61P 43/00 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2474910

The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an oligonucleotide composition including at least 2 different oligonucleotides targeted to a target gene. This invention also provides methods of inhibiting protein synthesis in a cell and methods of identifying oligonucleotide compositions that inhibit synthesis of a protein in a cell.

Les compositions oligonucléotidiques de l'invention utilisent une association d'oligonucléotides. Dans un aspect, l'invention concerne une composition oligonucléotidique comprenant au moins deux oligonucléotides différents dirigés contre un gène cible. L'invention concerne en outre des méthodes d'inhibition de la synthèse de protéines dans une cellule, et des méthodes d'identification de compositions oligonucléotidiques inhibant la synthèse d'une protéine dans une cellule.

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