Oligonucleotide conjugates

Details Oligonucleotide conjugates Oligonucleotide conjugates

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/7084 (2006.01) A61K 31/7088 (2006.01) A61P 35/00 (2006.01) C07H 21/04 (2006.01) C12N 9/10 (2006.01)

Patent

CA 2499082

Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system, are provided. In particular embodiments the oligonucleotide is complementary to the RNA component of human telomerase and is covalently attached to a nucleobase via an optional linker. The conjugates inhibit telomerase enzyme activity.

La présente invention concerne des conjugués d'oligonucléotide selon lesquels un oligonucléotide est lié par covalence à un système aromatique. Dans des modes de réalisation particuliers, l'oligonucléotide est complémentaire du composant ARN de la télomérase humaine et est lié par covalence à une nucléobase par l'intermédiaire d'un lieur facultatif. Les conjugués de la présente invention inhibent l'activité de l'enzyme télomérase.

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