Oligonucleotide conjugates

Details Oligonucleotide conjugates Oligonucleotide conjugates

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C12N 9/12 (2006.01) C12N 15/11 (2006.01) C12N 15/54 (2006.01)

Patent

CA 2440322

Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system are provided. In particular embodiments, the oligonucleotide, complementary to the RNA component of telomerase, is attached to a fluorophore. The conjugates inhibit telomerase enzyme activity.

L'invention porte sur des conjugués d'oligonucléotide dans lesquels un oligonucléotide est lié de manière covalente à un système aromatique. Selon des réalisations particulières, l'oligonucléotide, complémentaire au composant ARN de la télomérase, est lié à un fluorophore. Les conjugués inhibent l'activité de l'enzyme télomérase.

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