C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) A61K 31/70 (2006.01) A61K 41/00 (2006.01) C12N 9/96 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2197785
The invention pertains to an oligonucleotide characterized in that a transesterification or hydrolysis catalyst is bonded to the oligonucleotide, the inner sequence of the oligonucleotide is partially noncomplementary to a naturally occurring target RNA, and the oligonucleotide is composed of deoxyribonucleic acid units, unnatural synthetic nucleotide units or peptide nucleic acids. The oligonucleotides are extremely well suited for splitting a complementary target RNA, the oligonucleotide being released again after the splitting, thus showing a catalytic effect.
L'invention concerne un oligonucléotide caractérisé en ce qu'un catalyseur de transestérification ou d'hydrolyse est lié à l'oligonucléotide, et la séquence interne de l'oligonucléotide est partiellement non complémentaire d'un ARN cible présent dans la nature. L'oligonucléotide est constitué d'unités d'acide désoxyribonucléique, d'unités de nucléotide non naturelles synthétiques ou d'acides nucléiques peptidiques. Ces oligonucléotides se prêtent parfaitement à la division d'un ARN cible complémentaire, l'oligonucléotide étant de nouveau libéré après division, développant ainsi un effet catalytique.
Hall Jonathan
Haner Robert
Husken Dieter
Moser Heinz
Fetherstonhaugh & Co.
Novartis Ag
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