C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/87 (2006.01) A61K 9/127 (2006.01) A61K 9/48 (2006.01) C12N 15/88 (2006.01)
Patent
CA 2425193
Cells, liposomes and lipid particles are provided with complementary projecting oligonucleotides, which hybridize to bring them together as an aid to efficient fusion, which may be further aided by osmotic or electrical shock. The invention further provides complementary pairs of oligonucleotides containing moieties to anchor them in cellular and liposome membranes, as well as liposomes that carry agents to be introduced into cells and that are provided with membrane-bound projecting oligonucleotides.
Selon l'invention, des cellules, des liposomes et des particules lipidiques sont fournis avec des oligonucléotides dressés complémentaires, qui s'hybrident pour les rassembler en tant qu'auxiliaire pour une fusion efficace, laquelle peut être encore améliorée par un choc osmotique ou électrique. L'invention concerne des paires d'oligonucléotides complémentaires contenant des fragments destinés à les ancrer dans des membranes cellulaires ou liposomales, ainsi que des liposomes qui transportent des agents à introduire dans des cellules, et sont dotés d'oligonucléotides dressés fixés à la membrane.
Alsmadi Osama A.
Kramer Fred R.
Tyagi Sanjay
Mbm Intellectual Property Law Llp
The Public Health Research Institute Of The City Of New York Inc.
University Of Medicine And Dentistry Of New Jersey
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