Oligonucleotide inhibitors of mbd2/dna demethylase and uses...

Details Oligonucleotide inhibitors of mbd2/dna demethylase and uses... Oligonucleotide inhibitors of mbd2/dna demethylase and uses...

C - Chemistry, Metallurgy

12

N

C12N 9/10 (2006.01) A61K 48/00 (2006.01) C12N 15/11 (2006.01) C12N 15/52 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2530108

Oligonucleotide inhibitors that inhibit expression of a mammalian MBD2/DNA demethylase (MBD2/dMTase) are provided. The oligonucleotide inhibitors can be used to inhibit the growth or proliferation of tumour cells in vitro and in vivo. The use of the oligonucleotide inhibitors in the treatment of cancer and methods of identifying potential target genes for cancer therapy or diagnosis using the oligonucleotide inhibitors are also provided.

L'invention porte sur des inhibiteurs oligonucléotidiques qui inhibent l'expression d'un MBD2/ADN déméthylase mammifère (MBD2/dMTase). Ces inhibiteurs oligonucléotidiques peuvent servir à inhiber la croissance ou la prolifération de cellules tumorales in vitro et in vivo. L'invention concerne aussi l'utilisation d'inhibiteurs oligonucléotidiques dans le traitement du cancer et des procédés d'identification de gènes cibles potentiels pour la thérapie ou le diagnostic du cancer au moyen des inhibiteurs oligonucléotidiques.

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