Oligonucleotide mediated specific cytokine induction and in...

Details Oligonucleotide mediated specific cytokine induction and in... Oligonucleotide mediated specific cytokine induction and in...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/70 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2288222

The invention provides methods for modulating specific CMI-inducing cytokines in vivo. Such methods result in stimulation of the cytokines IL-6, IL-12 MIP- 1.beta. and MCP without substantially inducing undesired cytokines. The methods according to the invention are based upon administration of oligonucleotides containing particular structural motifs which lead to specific cytokine induction.

Nouvelles méthodes permettant de moduler des cytokines spécifiques induisant l'immunité à médiation cellulaire in vivo. Ces nouvelles méthodes entraînent la stimulation des cytokines IL-6, IL-12, MIP-1.beta. et MCP, sans induire de cytokines non désirées. Les méthodes selon la présente invention sont fondées sur l'administration d'oligonucléotides contenant des motifs structuraux particuliers qui conduisent à une induction spécifique des cytokines.

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