Oligonucleotide microarray

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/68 (2006.01)

Patent

CA 2539654

The present invention relates to oligonucleotide microarrays comprising short chemically modified RNA oligonucleotides and uses of such microarrays in genomics applications. More specifically, the invention provides an oligonucleotide array comprising a surface and a plurality of oligonucleotide, wherein at least one oligonucleotide has at least one modified sugar moiety at the 2'OH position. The microarrays of the invention are more specifically useful to detect small RNAs.

La présente invention concerne des jeux ordonnés de microéchantillons oligonucléotidiques, qui comprennent des oligonucléotides courts d'ARN chimiquement modifiés. Elle concerne également l'utilisation desdits jeux ordonnés de microéchantillons dans des applications génomiques. L'invention concerne plus particulièrement un jeu ordonné de microéchantillons oligonucléotidiques présentant une surface et plusieurs oligonucléotides, et dont au moins un oligonucléotide comprend au moins un fragment de sucre modifié à la position 2'OH. Les jeux ordonnés de microéchantillons de l'invention sont plus particulièrement utiles pour la détection de petits ARN.

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