C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) A61K 31/70 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2174315
Compositions and methods are provided for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of the synthesis or metabolism of multidrug resistance-associated protein (MRP). In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding multidrug resistance-associated protein (MRP). Methods of treating animals suffering from diseases or conditions amenable to therapeutic intervention by modulating multidrug resistance with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to multidrug resistance-associated protein (MRP) are disclosed. Methods of preventing the development of multidrug resistance and of improving the efficacy of chemotherapy are also disclosed.
Compositions et méthodes de traitement et de diagnostic de maladies ou d'affections relevant d'un traitement par modulation de la synthèse ou du métabolisme de la protéine associée à la résistance multiple aux anticancéreux (MRP). Dans les modes de réalisation préférés, on produit des oligonucléotides spécifiquement hybridables avec des acides nucléiques codant la protéine MRP. L'invention concerne également des méthodes de traitement d'animaux souffrant de maladies ou d'affections relevant d'une intervention thérapeutique par modulation de la résistance multiple aux anticancéreux au moyen d'un oligonucléotide spécifiquement hybridable avec de l'ADN ou de l'ARN et correspondant à la MRP. L'invention concerne en outre des méthodes de prévention de la résistance multiple aux anticancéreux et d'amélioration de la chimiothérapie.
Baracchini Edgardo Jr.
Bennett Clarence Frank
Borden Ladner Gervais Llp
Isis Pharmaceuticals Inc.
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