Oligonucleotide modulation of protein kinase c

Details Oligonucleotide modulation of protein kinase c Oligonucleotide modulation of protein kinase c

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C12N 9/12 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2132094

2132094 9319203 PCTABS00025 Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C. Oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding PKC. Oligonucleotides specifically hybridizable with a translation initiation site, 5'-untranslated region or 3'- untranslated region are provided. Oligonucleotides specifically hybridizable with a particular PKC isozyme or set of isozymes are also provided. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating protein kinase C expression with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to PKC are disclosed.

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