Oligonucleotide non-viral delivery systems

Details Oligonucleotide non-viral delivery systems Oligonucleotide non-viral delivery systems

A - Human Necessities

61

K

A61K 48/00 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2662560

Low molecular weight low molecular weight chitosan oligomers were able to self- assemble siRNA into nanosized particles, provide protection against enzymatic degradation, and mediate gene silencing that is stable over a long period of time in vitro. The control of structural variables in formulating complexes of siRNA with low molecular weight chitosans provides an efficient alternative delivery system for siRNA in vitro and in vivo.

L'invention concerne des oligomères de chitosane de faible poids moléculaire, qui peuvent induire l'auto-assemblage de l'ARNsi en nanoparticules, fournir une protection contre la dégradation enzymatique, et induire un silençage génique in vitro stable pendant une longue durée. La régulation de variables structurelles dans la formulation de complexes d'ARNsi comprenant des chitosanes de faible poids moléculaire fournit, in vitro et in vivo, un système d'apport substitutif efficient pour l'ARNsi.

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