Oligonucleotide-polyamide conjugates

Details Oligonucleotide-polyamide conjugates Oligonucleotide-polyamide conjugates

C - Chemistry, Metallurgy

07

H

195/1.12, 150/8.

C07H 21/04 (2006.01) A61K 47/48 (2006.01) C07H 21/00 (2006.01) C07K 7/02 (2006.01) C08G 69/08 (2006.01) C08G 69/42 (2006.01) C08G 69/48 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 1339205

Oligonucleotide-polyamide conjugates of the formula X-L-Y, where X is a polyamide, Y is an oligonucleotide, and L is a linker which forms a covalent bond with the amino-terminus of the polyamide X and the 3' phosphate group of the oligonucleotide Y. Conjugates may be synthesized by assembling a polyamide on a solid support matrix, adding a suitable linker molecule, followed by synthesis of the oligonucleotide. Methods for detecting specific polynucleotides with oligonucleotide-polyamide conjugates are also described.

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